The population was 106,595 in 2010 census, making it the 246th most populated city in the United States. 

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Pueblo is situated at the confluence of the Arkansas River and Fountain Creek, 112 miles south of the Colorado State Capital in Denver. The area is considered to be semi-arid desert land, with approximately 12 inches of precipitation annually. With its location in the "Banana Belt," Pueblo tends to get less snow than the other major cities in Colorado.

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The Historic Arkansas River Project (HARP) is a river walk in the Union Avenue Historic Commercial District and shows the history of the Pueblo Flood.

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One of the larges steel-producing cities in the United States, Pueblo is sometimes referred to as the "Steel City."

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Pueblo is the hometown of four Medal of Honor recipients - more per capita than any other city in the United States - Pueblo is also known as the "Home of the Heroes."